|
KMID : 0613820120220010001
|
|
Journal of Life Science
2012 Volume.22 No. 1 p.1 ~ p.6
|
|
|
Consumption of Jeju Ground Water Containing Vanadium Components Enhances Hepatic Antioxidant Defense Systems in ob/ob Mice
|
|
Kim A-Reum-Da-Seul
You Ho-Jin
Hyun Jin-Won
|
|
|
Abstract
|
|
|
|
The present study examined the effects of consumption of Jeju ground water containing vanadium components on oxidative stress in obese (ob/ob) mice. Intake of Jeju ground water decreased the generation of oxidative stress induced-lipid peroxidation in the liver of ob/ob mice It also enhanced the enzymatic antioxidant defense system by increasing the protein expression and activity of superoxide dismutase, catalase, and glutathione peroxidase in liver tissues. Jeju ground water intake also upregulated the intracellular content of reduced glutathione. The induction of antioxidant enzyme expression by consumption of Jeju ground water was mediated by the erythroid transcription factor NF-E2 (Nrf2). Increased nuclear expression of phospho Nrf2 was observed in ob/ob mouse liver cells following ntake of Jeju ground water. These results suggest that consumption of Jeju ground water stimulated the antioxidant defense system in the livers of ob/ob mice via induction of Nrf2.
|
|
|
KEYWORD
|
|
|
Jeju ground water, ob/ob mice, antioxidant defense system, erythroid transcription factor NF-E2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|